Metformin (dimethylbiguanide) features as a current first-line pharmacological treatment for type 2 diabetes (T2D) in almost all guidelines and recommendations worldwide. It has been known that the antihyperglycemic effect of metformin is mainly due to the inhibition of hepatic glucose output, and therefore, the liver is presumably the primary site of metformin function. However, in this issue of Diabetes Care, Fineman and colleagues (1) demonstrate surprising results from their clinical trials that suggest the primary effect of metformin resides in the human gut.
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Support Center Support Center -Metformin, if not contraindicated, is the preferred initial pharmacologic agent for treatment of type 2 diabetes mellitus. Annual Reporting and Auditing
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How should this medicine be used? Altered Mental Status: Metformin is primarily used for type 2 diabetes, but is increasingly being used in polycystic ovary syndrome due to the linkage between these two conditions. Outcomes appear to be improved even in those with some degree of kidney disease, heart failure, or liver problems.
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Taking Metformin should only be used to complement the benefits of a healthy diet and regular physical activity as opposed to replacing these aspects of a healthy lifestyle.
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Small sore(s) (ulcer) on the foot or leg: Any non-healing sore or ulcer on the feet or legs of someone with diabetes needs to be seen by a medical professional right away. A sore less than 1 inch across, not draining pus, and not exposing deep tissue or bone, can safely be evaluated by a health-care professional, as long as the patient does not have fever and their blood sugar levels are under control.
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